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Factors affecting pregnancy outcome resulting from assisted reproductive technology (ART)
C Zhou1, D C Knight, J P Tyler
1Department of Obstetrics and Gynecology, First Affiliated Hospital of Sun Yat-sen University of Medical Science, China.
The Journal of Obstetrics and Gynaecology Research
|January 8, 1999
Summary
Maternal age is the primary factor influencing miscarriage rates in assisted reproduction technologies (ART) pregnancies, with a significant increase observed after age 38. Other analyzed variables did not significantly impact pregnancy outcomes.
Area of Science:
- Reproductive Medicine
- Obstetrics and Gynecology
- Infertility Research
Background:
- Assisted reproduction technologies (ART) offer solutions for infertility.
- Understanding factors affecting miscarriage in ART pregnancies is crucial for improving outcomes.
Purpose of the Study:
- To identify factors influencing miscarriage rates in pregnancies achieved through ART.
- To analyze the relationship between maternal age and other variables with pregnancy outcomes in ART.
Main Methods:
- Retrospective observational study of 794 ART pregnancies.
- Grouped pregnancies into 'miscarriage' and 'term birth' based on ultrasound.
- Analyzed data using regression analyses and t-tests.
Main Results:
- Maternal age showed a statistically significant positive correlation with spontaneous abortion rate (p=0.008), increasing notably after 38 years.
- No significant difference in oocyte retrieval numbers between groups.
- Maternal age negatively correlated with oocyte yield (p<0.001), but this did not affect live birth rates.
Conclusions:
- Maternal age is the most significant factor affecting pregnancy outcomes in ART.
- No other analyzed variables were found to be major determinants of miscarriage after conception.