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Updated: Jul 28, 2026
Hand Controlled Manipulation of Single Molecules via a Scanning Probe Microscope with a 3D Virtual Reality Interface
Published on: October 2, 2016
Development and validation of a nanometer manipulation and measurement system for biomechanical testing of single
Abstract:
A biomechanical testing system for single macro-molecules has been developed using optical tweezers. To achieve nanometer manipulation and measurement, a piezo-stage and an interferometer were adopted. A systematic calibration was then performed on the displacement resolution. The piezo-stage has a noise level around 1 nm standard deviation, and the interferometer has a noise level of less than 5 nm standard deviation. The results revealed that the system has a nanometer resolution which is sufficient for the measurement of deformation and stiffness of single macro-molecules.
