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Acute-phase changes in children recovering from minor surgery
E Günel1, O Cağlayan, F Cağlayan
1Departments of Pediatric Surgery, Biochemistry and Public Health, Selçuk University, School of Medicine, Konya, Turkey.
Pediatric Surgery International
|January 9, 1999
Summary
The prognostic inflammatory and nutritional index (PINI) better reflects the metabolic response to surgical stress in children after minor surgery compared to individual proteins like albumin and C-reactive protein.
Area of Science:
- Biochemistry
- Surgical Metabolism
- Pediatric Surgery
Background:
- Surgical stress triggers metabolic changes, including altered protein synthesis and plasma concentrations.
- Identifying reliable biomarkers is crucial for monitoring patient recovery post-surgery.
Purpose of the Study:
- To evaluate specific proteins and the prognostic inflammatory and nutritional index (PINI) as clinical indicators of metabolic response to surgical stress in children.
- To determine the most effective index for monitoring recovery after minor surgical procedures.
Main Methods:
- Studied 44 children undergoing elective inguinal surgery.
- Measured albumin (AL), Prealbumin (PA), C-reactive protein (CRP), and a1-acid glycoprotein (AGP) preoperatively and on postoperative days 1 and 5.
- Calculated the prognostic inflammatory and nutritional index (PINI) using these protein values.
Main Results:
- Albumin levels remained stable; Prealbumin decreased significantly on day 1.
- C-reactive protein and a1-acid glycoprotein levels increased postoperatively, remaining elevated on day 5.
- PINI showed significant changes, with higher values post-surgery compared to preoperative levels, and greater percent changes than individual proteins.
Conclusions:
- The prognostic inflammatory and nutritional index (PINI) is a more valuable indicator of the metabolic response to surgical stress in children recovering from minor surgery.
- PINI offers a comprehensive assessment compared to individual acute-phase proteins.
- This finding aids in optimizing patient monitoring and management after pediatric surgical procedures.