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fMLP-OMe analogs substituted at the methionine residue: an insight into the receptor properties
G Cavicchioni1, L G Monesi, M E Ferretti
1Department of Pharmaceutical Sciences, University of Ferrara, Italy.
Archiv Der Pharmazie
|January 9, 1999
Abstract:
In order to obtain an insight into the mode of binding at the for-Met-Leu-Phe-OH (fMLP) receptor, three fMLP-OMe analogs (1-3) were synthesized in which the Met residue was substituted by Gln 1, Asn 2, and Ser 3. We evaluated the influence of the charge variation and/or the shift of its position on neutrophil biological responses.