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Related Experiment Videos

Perineuronal nets: past and present

M R Celio1, R Spreafico, S De Biasi

  • 1Institute of Histology and General Embryology, and Programme in Neurosciences, University of Fribourg, Switzerland.

Trends in Neurosciences
|January 9, 1999
PubMed
Summary
This summary is machine-generated.

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The perineuronal net, a structure adhering to nerve cells, is a complex of extracellular matrix molecules. Once dismissed, it is now recognized for its crucial role in neurocytology and neuroscience.

Area of Science:

  • Neuroscience
  • Neurocytology
  • Extracellular Matrix

Background:

  • The perineuronal net, initially termed peripheral reticulum, was conceptualized alongside the Golgi apparatus.
  • Early observations were often dismissed as staining artifacts, hindering its recognition.

Observation:

  • This structure adheres intimately to nerve cell surfaces.
  • It is composed of extracellular matrix molecules.
  • It is difficult to distinguish from surrounding glial processes.

Findings:

  • The perineuronal net is a genuine and significant entity in neurocytology.
  • Interest in this structure has fluctuated throughout scientific history.
  • Historical morphological studies anticipated current understanding of its function.

Related Experiment Videos

Implications:

  • Revisiting the history of the perineuronal net highlights the value of keen morphological observation.
  • Understanding the perineuronal net is crucial for advancing neurocytology.
  • Its complex nature suggests diverse roles in neural function and plasticity.