Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hepatitis after alendronate

R J Lieverse

    The Netherlands Journal of Medicine
    |January 12, 1999
    PubMed
    Summary

    Severe hepatitis in a 77-year-old woman was potentially caused by alendronate medication. The liver inflammation resolved after discontinuing alendronate, suggesting a causal link.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Adherence to guideline recommendations for Barrett's esophagus (BE) surveillance endoscopies: Effects of dedicated BE endoscopy lists.

    Endoscopy international open·2023
    Same author

    [Acute pancreatitis, a protocol for diagnosis and treatment].

    Nederlands tijdschrift voor geneeskunde·2002
    Same author

    [Reduced risk of complications associated with severe acute (necrotizing) pancreatitis by administration of antibiotics; results from a literature review].

    Nederlands tijdschrift voor geneeskunde·2002
    Same author

    Necrotizing enterocolitis in a married couple due to a staphylococcal toxin.

    European journal of gastroenterology & hepatology·2001
    Same author

    Obese women are less sensitive for the satiety effects of bombesin than lean women.

    European journal of clinical nutrition·1998
    Same author

    Gallbladder motility in response to sham feeding and cholecystokinin in lean and obese subjects.

    Digestion·1997

    Area of Science:

    • Hepatology
    • Pharmacology
    • Internal Medicine

    Background:

    • Alendronate is a bisphosphonate commonly prescribed for osteoporosis.
    • Drug-induced liver injury (DILI) is a significant clinical concern.
    • Hepatitis can have various etiologies, necessitating thorough investigation.

    Observation:

    • A 77-year-old female patient presented with severe hepatitis.
    • Extensive workup excluded common causes of hepatitis, including viral and autoimmune etiologies.
    • The patient was concurrently taking alendronate for osteoporosis.

    Findings:

    • Cessation of alendronate medication led to the resolution of severe hepatitis.
    • This temporal relationship strongly suggests alendronate as the causative agent.
    • Liver function tests normalized post-discontinuation of the drug.

    Implications:

    • Alendronate should be considered as a potential cause of severe hepatitis in patients presenting with unexplained liver injury.
    • Clinicians should maintain a high index of suspicion for DILI when prescribing bisphosphonates.
    • Further research may be warranted to elucidate the mechanism of alendronate-induced hepatotoxicity.

    Related Experiment Videos