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Novel methods of insulin delivery: an update
1Controlled Drug-Delivery Research Center, Rutgers University College of Pharmacy, Piscataway, NJ 08854-8067, USA.
Critical Reviews in Therapeutic Drug Carrier Systems
|January 12, 1999
Summary
Exploring alternative insulin delivery methods beyond injections can improve diabetes management. Novel routes like nasal, oral, and transdermal insulin show promise for better systemic delivery and glucose control.
Area of Science:
- Endocrinology and Metabolism
- Pharmacology and Pharmaceutical Sciences
Background:
- Conventional insulin therapy relies on multiple daily subcutaneous injections, which do not fully replicate physiological insulin secretion.
- This discrepancy can lead to suboptimal systemic insulin disposition and blood glucose regulation.
Purpose of the Study:
- To review and summarize various alternative routes for systemic insulin delivery.
- To assess the potential of these novel methods in improving diabetes treatment.
Main Methods:
- Literature review of studies investigating non-injection routes for insulin administration.
- Analysis of reported efficacy in achieving systemic insulin delivery and glucose reduction.
Main Results:
- Peroral and nasal insulin administration show significant potential for diabetes treatment.
- Facilitated transdermal, pulmonary, buccal, and ocular routes have demonstrated success in systemic delivery and lowering serum glucose.
- Rectal, vaginal, and uterine routes have also been explored for systemic insulin delivery.
Conclusions:
- Alternative insulin delivery routes offer promising alternatives to conventional injections.
- These methods aim to improve insulin disposition and achieve better glycemic control in diabetes management.