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The new antidepressants. Selective serotonin reuptake inhibitors
M J Labellarte1, J T Walkup, M A Riddle
1Division of Child and Adolescent Psychiatry, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
Abstract:
This article provides a resource for choosing among available SSRIs to treat pediatric patients. SSRIs are addressed according to five areas of interest: treatment efficacy data, untoward effects profile, pharmacokinetic characteristics, potential drug-drug interactions, and cost. Strategies for SSRI dosing and pretreatment work-up are also discussed. Included in the article is a reference table for SSRI dosing, available preparations, and cost per dose. Also included is an abbreviated reference table of important cytochrome P-450 isoenzymes, isoenzyme inhibition by SSRIs, and selected psychotropic and somatic medication substrates.