Comparative study of BacT/Alert FAN bottles and standard BacT/Alert bottles

A total of 5,230 paired blood cultures were studied. One sample was divided between aerobic and anaerobic BacT/Alert standard bottles, and the other divided between aerobic and anaerobic BacT/Alert FAN bottles. There were 44 occasions where Staphylococcus aureus was recovered only from the FAN bottles, compared to six where only the standard bottles were positive (p < 0.001), and 21 occasions where Escherichia coli was isolated only from FAN bottles, compared to eight occasions where only the standard bottles were positive for this organism (p < 0.05). In 21 of 28 cases reviewed where S. aureus was isolated from FAN bottles only the patient had been receiving anti-staphylococcal antibiotics. However, only 2 of 30 cases where Gram-negative bacilli were isolated from FAN bottles had documented recent appropriate antibiotic therapy. Patients in whom FAN bottles are more likely to recover organisms cannot be selected on the basis of documented antibiotic treatment.