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Seroprevalence of cytomegalovirus infection in children
C Pancharoen1, P Bhattarrakosol, U Thisyakorn
1Department of Pediatrics, Bhumibol Adulyadej Hospital, Bangkok, Thailand.
Insights
This study found high cytomegalovirus (CMV) infection rates in hospitalized infants, particularly in younger age groups. Lower family income was linked to increased CMV antibody presence in infants.
Area of Science:
- Virology
- Pediatrics
- Public Health
Background:
- Cytomegalovirus (CMV) is a common virus that can cause serious health issues in infants.
- Understanding CMV seroprevalence in hospitalized infants is crucial for early detection and management.
- Previous research highlights varying CMV infection rates across different pediatric populations.
Purpose of the Study:
- To determine the seroprevalence of cytomegalovirus (CMV) infection among hospitalized infants.
- To investigate potential correlations between CMV infection and demographic factors in infants.
- To provide data on CMV epidemiology in a specific pediatric hospital setting.
Main Methods:
- A hospital-based cross-sectional survey was conducted.
- Data collected from 83 hospitalized infants (46 boys, 37 girls) aged 0-24 months.
- Serological testing for CMV antibodies was performed; demographic and socioeconomic data were gathered.
Main Results:
- Overall CMV seroprevalence was high, with rates ranging from 61.90% to 80.95% across age groups (0-24 months).
- Excluding infants under 6 months, the seroprevalence rate was 70.97%.
- Infants with positive CMV antibodies had significantly lower family income compared to those with negative results. No correlations found with age, sex, family size, or rearing location.
Conclusions:
- Hospitalized infants exhibit a high seroprevalence of cytomegalovirus (CMV) infection.
- Lower socioeconomic status, indicated by family income, is associated with increased CMV infection risk in this population.
- Further research into transmission routes and preventative strategies for CMV in vulnerable infant populations is warranted.
Abstract:
A hospital-based cross-sectional survey was conducted in Bhumibol Adulyadej Hospital between February and May 1997 to study the seroprevalence of cytomegalovirus (CMV) infection in hospitalized infants. Of 83 cases, 46 were boys and 37 girls, with the mean age of 11.87 months. The seroprevalence of CMV infection was 80.95, 61.90, 80.95 and 70.00% in infants at the age range of 0-6, 6-12, 12-18 and 18-24 months respectively. After excluding infants below 6 months of age, the seroprevalence rate was 70.97%. The family income of infants with positive CMV antibody was significantly lower than that of infants with negative results. There were no statistical correlations between seroconversion and age, sex, number of children in family and place of child rearing.