Related Experiment Video
Updated: Aug 15, 2026
Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
Published on: February 9, 2011
[Septicemia associated with central venous catheterization in a children's hospital. A multivariate study]
R Herruzo Cabrera1, J Díez Sebastián, A Baylin Larios
1Servicio de Medicina Preventiva, Hospital La Paz, Madrid.
Insights
Bloodstream infections (BSI) in children are common with central venous catheters. Key predictors for removal include skin colonization, antibiotic duration, lipid solutions, and fever, aiding clinical decisions.
Area of Science:
- Pediatric Infectious Diseases
- Hospital Epidemiology
- Medical Device Infections
Background:
- Bloodstream infections (BSI) represent a significant nosocomial infection in pediatric hospitals.
- Central venous catheterization is frequently associated with these infections in children.
- Identifying risk factors is crucial for preventing and managing these complications.
Purpose of the Study:
- To estimate the incidence of BSI associated with central venous catheterization in children.
- To identify risk and protective factors for catheter-related infections using multivariate analysis.
Main Methods:
- Prospective study of 489 central venous catheters in children over 6 months.
- Data collected included insertion site, catheter type, duration, clinical info, microbiology, and treatments.
- Multivariate logistic regression analysis was performed for catheter colonization and BSI.
Main Results:
- Catheter-related BSI incidence was 5.5%; local infection was 11.2%.
- Incidence density was 3.15 for BSI and 6.42 for local infection per 1,000 catheter-days.
- Predictors for infection included skin colonization (>15 colonies), antibiotic days, lipid parenteral solutions, and fever (ROC AUC 0.72).
Conclusions:
- Colonization (>15 colonies) at the insertion site is a key predictor for catheter removal in pediatric septicemia.
- Use of lipidic parenteral solutions and extended antibiotic treatment are also important factors.
- These criteria aid in clinical decision-making regarding catheter withdrawal.
Background:
The blood stream infections (BSI) are the principal nosocomial infection in the child hospitals. In this study we estimate the incidence of BSI associated with central venous catheterization, and estimate different risk and protective factors, through a multivariate study.
Material And Methods:
The study have followed in a prospective way during 6 months all the children with central venous catheterization (489 catheters), from the moment of insertion until withdrawal, collecting various data previous to the development of the infection: place of insert, type of catheter, duration, clinic information, microbiology, and the treatments administered through the catheter. In was accomplished an multivariate analysis with logistic regression, for two principal effect variables, the catheter colonization and the catheter related BSI.
Results:
The incidence of catheter related BSI was 5.5% and for local infection 11.2%. The density of incidence was 3.15 and 6.42 for each 1,000 catheters-day, respectively. The logistic regression model included: colonization of the skin in the insertion point > 15 colonies, days with antibiotics through catheter, use of lipidic parenteral solutions and fever, previous to the infection. The area under the ROC curve was 0.72.
Conclusions:
In children with septicemias associated with central catheterization the predictors or sentry criterion for the decision on when to withdraw a catheter are colonization (> 15 colonies) of the insert point, together with the use of lipidic parenteral solutions or extended antibiotic treatment.
