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Apoptosis. Basic concepts and implications in coronary artery disease
P J Best1, D Hasdai, G Sangiorgi
1Department of Internal Medicine and Cardiovascular Diseases of Biochemistry, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA.
Arteriosclerosis, Thrombosis, and Vascular Biology
|January 15, 1999
Summary
Apoptosis, a regulated cell death, is implicated in coronary artery disease pathogenesis. This review covers apoptosis detection, regulation, and its role in cardiovascular disease.
Area of Science:
- Cardiovascular Biology
- Cell Death Mechanisms
Background:
- Apoptosis is a distinct, regulated form of cell death.
- Evidence suggests apoptosis contributes to coronary atherosclerotic disease, restenosis, and transplant arteriopathy.
- Increased markers of apoptosis are observed in these conditions.
Purpose of the Study:
- To review the detection methods for apoptosis.
- To discuss the regulation of apoptosis by vasoactive substances.
- To explore the role of apoptosis in coronary artery disease pathogenesis.
Main Methods:
- Review of existing literature on apoptosis.
- Analysis of anatomical and biochemical evidence.
- Examination of the effects of nitric oxide and angiotensin II on vascular smooth muscle cell apoptosis.
Main Results:
- Apoptosis is anatomically evident in various cardiovascular conditions.
- Vasoactive substances differentially regulate vascular smooth muscle cell apoptosis.
- Nitric oxide may induce apoptosis, while angiotensin II may inhibit it.
Conclusions:
- Apoptosis is a significant factor in coronary artery disease.
- Understanding apoptosis regulation is crucial for cardiovascular disease research.
- Further investigation into apoptosis's role in cardiovascular pathology is warranted.