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Effects of fluoxetine administration on mu-opoid receptor immunostaining in the rat forebrain
J M de Gandarias1, E Echevarría, I Acebes
1Department of Physiology, School of Medicine, University of the Basque Country, PO Box 699, Bilbao, Spain.
Brain Research
|January 16, 1999
Abstract:
Fluoxetine is a selective serotonin reuptake inhibitor. Analysis of mu-opioid receptor immunostaining after chronic fluoxetine administration in rats revealed an increase in the density of cells expressing mu-opioid receptors in the caudatus-putamen, the dentate gyrus, the lateral septum and the frontal, parietal and piriform cortices. These data suggest that mu-opioid receptor expression in the rat forebrain is altered by in vivo chronic fluoxetine treatment.