[The effect of nimodipine on a local ischemic brain lesion]

A modified rat model of ischemic brain injury caused by ligation of the middle cerebral artery is proposed. The time course of morphological changes in brain tissues was studied and bilateral cerebral circulatory disorders, hypoxic cortical neurocytic damages followed by intracellular regeneration, as well as metabolic and structural changes not only in the cortical neurocytes, but in the conduction paths and synaptic terminals. Nimodipine had no effect on blood supply to the ischemic brain either early or late in ischemic brain injury after ligation of the middle cerebral artery.