Related Experiment Video
Updated: Jul 22, 2026

Fabrication and Operation of an Oxygen Insert for Adherent Cellular Cultures
Published on: January 6, 2010
The genesis of ISOTT. International Society on Oxygen Transport to Tissue
1Department of Chemical and Biochemical Engineering, University of Maryland Baltimore County, Baltimore 21250, USA.
The International Society on Oxygen Transport to Tissue (ISOTT) was founded in April, 1973 by Drs. Duane F. Bruley and Haim I. Bicher. Dr. Bruley first wanted to sponsor an international symposium on oxygen transport to tissue to highlight the research activity between his group at Clemson University in Clemson, South Carolina and Dr. Melvin H. Knisely's group at the Medical College of South Carolina in Charleston, South Carolina. At the same time it was hoped to honor Dr. Knisely for his ingenious development of the Quartz Rod Crystal technique for observing blood flow in-vivo. In discussions with Dr. Knisely's wife, Verona, it was decided to sponsor a meeting that was jointly held at Clemson and Charleston. When Dr. Bicher returned from an extended trip abroad, he agreed to join the effort and he organized the program from the Medical College while Dr. Bruley handled all arrangements at Clemson University. After getting an overwhelming response to their initial call for papers from the international community, Drs. Bruley and Bicher made the decision to found an International Society. They then decided on a name, developed the society logo, assigned a mission, developed a charter, sketched the by-laws, and selected charter members to comprise the first international committee. The unique characteristics of the new society were to include a focus on inter and cross-disciplinary research involving theoretical and experimental investigations of oxygen transport to tissue. The intent was to bring life scientists and engineers together to examine the many complex phenomena of normal tissue growth and maintenance as well as tissue survival and repair under pathological conditions. Drs. Bruley and Bicher solicited Dr. Melvin Knisley as an honorary first President of the Society. At the meeting April 22-28, in Charleston/Clemson the first elected president was determined to be Dr. Melvin H. Kinsely. It was decided that in alternate years the meeting would be held in the United States and otherwise in Europe or Asia. The society has met around the world and is now celebrating its 25th Anniversary.
The International Society on Oxygen Transport to Tissue (ISOTT) was founded in April, 1973 by Drs. Duane F. Bruley and Haim I. Bicher. Dr. Bruley first wanted to sponsor an international symposium on oxygen transport to tissue to highlight the research activity between his group at Clemson University in Clemson, South Carolina and Dr. Melvin H. Knisely's group at the Medical College of South Carolina in Charleston, South Carolina. At the same time it was hoped to honor Dr. Knisely for his ingenious development of the Quartz Rod Crystal technique for observing blood flow in-vivo. In discussions with Dr. Knisely's wife, Verona, it was decided to sponsor a meeting that was jointly held at Clemson and Charleston. When Dr. Bicher returned from an extended trip abroad, he agreed to join the effort and he organized the program from the Medical College while Dr. Bruley handled all arrangements at Clemson University. After getting an overwhelming response to their initial call for papers from the international community, Drs. Bruley and Bicher made the decision to found an International Society. They then decided on a name, developed the society logo, assigned a mission, developed a charter, sketched the by-laws, and selected charter members to comprise the first international committee. The unique characteristics of the new society were to include a focus on inter and cross-disciplinary research involving theoretical and experimental investigations of oxygen transport to tissue. The intent was to bring life scientists and engineers together to examine the many complex phenomena of normal tissue growth and maintenance as well as tissue survival and repair under pathological conditions. Drs. Bruley and Bicher solicited Dr. Melvin Knisley as an honorary first President of the Society. At the meeting April 22-28, in Charleston/Clemson the first elected president was determined to be Dr. Melvin H. Kinsely. It was decided that in alternate years the meeting would be held in the United States and otherwise in Europe or Asia. The society has met around the world and is now celebrating its 25th Anniversary.
Related Concept Videos
Gas Exchange and Transport
Special considerations while measuring oxygen saturation
Ensuring accuracy in vital sign recordings while prioritizing patient comfort and minimizing anxiety is important.
Oxygen Transport in the Blood
Oxygen Delivering System I: Nasal Cannula and Face Mask
Nasal Cannula
A nasal cannula is a lightweight tube split at one end into two prongs and placed in the nostrils. It is typically used to deliver low to medium levels of oxygen.
Suggested flow rate: The suggested flow rate for a nasal cannula typically ranges between 1 and 6 L/min.
Oxygen percentage setting:...
Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen
Venturi Mask
The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...
Oxygen Requirements and Growth Patterns

