Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Macromolecular aspartate aminotransferase

J Tharakan1, A Hossenbocus, M J Arthur

  • 1Department of Medicine and Gastroenterology, St Mary's Hospital, Newport, Isle of Wight.

European Journal of Gastroenterology & Hepatology
|January 23, 1999
PubMed
Summary

Macroenzymes are larger serum enzymes. A rare case of elevated aspartate aminotransferase (AST) was caused by macroenzyme formation, preventing unnecessary patient procedures.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hypomelanosis of ito : a rare neurocutaneous syndrome.

Neurology India·2018
Same author

Introducing survival ethics into engineering education and practice.

Science and engineering ethics·2011
Same author

Referral of epileptic patients in North East Coast of West Malaysia an area with poor MRI coverage: an analysis.

The Southeast Asian journal of tropical medicine and public health·2007
Same author

Epilepsy surgery on dysembryoplastic neuroepithelial tumours.

The Medical journal of Malaysia·2007
Same author

Computed tomography perfusion of ischaemic stroke patients in a rural Malaysian tertiary referral centre.

Singapore medical journal·2006
Same author

Oblique vein of Marshall.

Heart (British Cardiac Society)·2005

Area of Science:

  • Biochemistry
  • Clinical enzymology

Background:

  • Macroenzymes are enzymes with higher molecular weight than their standard counterparts.
  • Elevated serum enzyme levels can indicate various health issues, necessitating diagnostic evaluation.

Observation:

  • Serum aspartate aminotransferase (AST) rarely forms complexes with immunoglobulins, leading to increased activity.
  • This phenomenon, known as macroenzyme formation, can mimic other pathologies.

Findings:

  • The study reports a patient with elevated AST levels attributed to macroenzyme formation.
  • This specific case highlights the clinical significance of recognizing macroenzymes.

Implications:

  • Awareness of macroenzyme formation is crucial for clinicians to avoid misdiagnosis.

Related Experiment Videos

  • Identifying macroenzymes can prevent patients from undergoing unnecessary, invasive, and costly diagnostic procedures.