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Oestrogen in human pregnancy faeces

H Adlercreutz, F Martin

    Acta Endocrinologica
    |October 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Pregnancy feces contain high levels of various estrogens, with unconjugated forms dominating. Fecal excretion of estradiol-17 beta is as significant as urinary excretion during pregnancy.

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    Area of Science:

    • Endocrinology
    • Gastroenterology
    • Steroid Metabolism

    Background:

    • Estrogen metabolism and excretion are crucial during pregnancy.
    • The role of fecal excretion in eliminating steroid hormones is not fully understood.

    Purpose of the Study:

    • To identify and quantify estrogens in human pregnancy feces.
    • To compare fecal and urinary estrogen excretion during pregnancy.

    Main Methods:

    • Qualitative analysis using gas chromatography-mass spectrometry.
    • Quantitative analysis using mass fragmentography on 24-hour pooled fecal samples from pregnant women.

    Main Results:

    • Identified 12 different estrogens in pregnancy feces, including estriol, estrone, and estradiol-17 beta.

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  • Total estrogen excretion ranged from 786 to 1300 μg/24h, with over 97% in unconjugated form.
  • Estradiol-17 beta and estriol were the most abundant estrogens; fecal excretion was comparable in importance to urinary excretion.

    • Conclusions:

    • Fecal excretion is a major route for eliminating estradiol-17 beta during pregnancy.
    • Bacterial enzyme action may contribute to the formation of fecal estrogens.
    • Ring D alpha-ketolic estrogens are present in trace amounts in feces, unlike in bile and urine.