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Autoimmunity in patients with Pemphigus foliaceus
Acta Allergologica
|August 1, 1976
Summary
Autoimmunity may play a role in Pemphigus foliaceus. Researchers detected gastric parietal cell and mitochondrial antibodies in some patients, suggesting a potential autoimmune link in this skin condition.
Area of Science:
- Immunology
- Dermatology
- Autoimmunity
Background:
- Pemphigus foliaceus (South American pemphigus) is a blistering skin disease.
- The potential role of autoimmunity in its pathogenesis requires further investigation.
Purpose of the Study:
- To investigate the presence of conventional autoantibodies in patients with Pemphigus foliaceus.
- To explore the association between autoantibodies and Pemphigus foliaceus.
Main Methods:
- Sera from 28 patients diagnosed with Pemphigus foliaceus were analyzed.
- Standard immunological assays were used to detect various autoantibodies.
Main Results:
- Gastric parietal cell antibody was identified in 6 patients (21.4%).
- Mitochondrial antibody was detected in 2 of those patients.
- Smooth muscle antibody was found in 1 patient. Nuclear factors, rheumatoid factors, and antibodies against glomerular components, salivary duct, and thyroglobulin were not detected.
Conclusions:
- The findings suggest a potential role for autoimmunity in Pemphigus foliaceus.
- Specific autoantibodies, such as gastric parietal cell and mitochondrial antibodies, may be associated with the condition.