Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

HLA patterns and disease associations

S E Ritzmann

    JAMA
    |November 15, 1976
    PubMed
    Summary
    This summary is machine-generated.

    The Human Leukocyte Antigen (HLA) system is crucial for immune defense and disease association. HLA testing aids in transplantation, disease diagnosis, and risk prediction, revealing links between specific antigens and various conditions.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Lactate dehydrogenase isoenzyme 1. A rapid assay for ischemic myocardial disease.

    Archives of internal medicine·1983
    Same author

    Bence Jones proteins: present diagnostic approaches.

    Laboratory and research methods in biology and medicine·1983
    Same author

    Immune complexes: characteristics, clinical correlations, and interpretive approaches in the clinical laboratory.

    Clinical chemistry·1982
    Same author

    Interferences of mannitol with phosphate determination.

    American journal of clinical pathology·1982
    Same author

    Salicylate mimicking an abnormal CK-isoenzyme.

    Clinical chemistry·1981
    Same author

    Chemical distinctions among body fluids.

    Clinical chemistry·1981
    Same journal

    Alcohol-Related Liver Disease: A Review.

    JAMA·2026
    Same journal

    Online Prescribing of GLP-1 Receptor Agonists.

    JAMA·2026
    Same journal

    Using AI Disagreement to Expose Gaps in Coverage Rules.

    JAMA·2026
    Same journal

    Randomized Trials in Pregnancy.

    JAMA·2026
    Same journal

    Randomized Trials in Pregnancy-Reply.

    JAMA·2026
    Same journal

    WHO Issues Guidelines for Treating Ebola and Marburg Viruses.

    JAMA·2026
    See all related articles

    Area of Science:

    • Immunogenetics
    • Molecular Biology
    • Medical Diagnostics

    Background:

    • The biological significance of the highly polymorphic histocompatibility complex (HLA) is not fully understood.
    • The HLA system is teleologically vital for species and individual survival, providing immune recognition and defense mechanisms.
    • HLA's role extends beyond transplantation, impacting disease diagnosis, prognosis, and risk prediction.

    Purpose of the Study:

    • To explore the multifaceted role of the Human Leukocyte Antigen (HLA) system in health and disease.
    • To highlight the diagnostic and prognostic applications of HLA testing.
    • To investigate the association between specific HLA antigens and various diseases.

    Main Methods:

    • Review of existing literature on HLA system's biological significance and clinical applications.

    Related Experiment Videos

  • Analysis of disease associations with specific HLA antigens.
  • Categorization of HLA-associated diseases based on certainty (certain, probable, statistically possible).

    • Main Results:

    • HLA testing is valuable for donor selection in transplantation.
    • HLA antigen associations are increasingly identified with diseases, particularly arthritides, autoimmune conditions, and infections.
    • These associations suggest shared etiologic or pathogenic mechanisms.
    • Diseases with HLA links can be classified by the strength of their association.

    Conclusions:

    • The Human Leukocyte Antigen (HLA) system plays a critical role in immune surveillance and disease pathogenesis.
    • HLA typing is a valuable tool for disease risk prediction, diagnosis, and prognosis.
    • Further research into HLA-disease associations can elucidate underlying biological mechanisms.