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Related Experiment Videos

Effects of ketamine on canine cardiovascular function

F A Diaz, J A Bianco, A Bello

    British Journal of Anaesthesia
    |October 1, 1976
    PubMed
    Summary

    Ketamine slightly decreased left ventricular contractility in dogs, with effects influenced by arterial pressure changes. This study provides evidence for a minor, temporary negative inotropic effect of ketamine.

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    Area of Science:

    • Cardiology
    • Pharmacology
    • Physiology

    Background:

    • Understanding ketamine's cardiovascular effects is crucial for its clinical application.
    • Left ventricular contractility is a key indicator of cardiac function.

    Purpose of the Study:

    • To assess the impact of ketamine on left ventricular contractility.
    • To investigate the relationship between ketamine dosage and its effects on myocardial function.

    Main Methods:

    • Eight canine right heart bypass preparations were used.
    • Left ventricular contractility was measured using maximum left ventricular dp/dt, ejection fraction, and pressures.
    • Measurements were taken before and during peak ketamine effect at constant heart rate and inflow.

    Main Results:

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    • Ketamine significantly decreased myocardial contractility.
    • A potential dose-response pattern was observed.
    • Ketamine induced mild, sustained, non-dose-dependent vasodilation, influencing its cardiac effects.

    Conclusions:

    • Ketamine exhibits a small and transient negative inotropic effect.
    • Cardiovascular effects of ketamine are partly mediated by changes in arterial pressure.