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Zinc deficiency and acrodermatitis after intravenous hyperalimentation
Archives of Dermatology
|July 1, 1978
Summary
A severe skin rash linked to intravenous hyperalimentation (IVH) resolved rapidly with zinc sulfate therapy. This case highlights zinc deficiency as a potential cause of IVH-associated dermatological issues.
Area of Science:
- Dermatology
- Nutritional Science
Background:
- Intravenous hyperalimentation (IVH) is a critical nutritional support method.
- Skin complications can arise during prolonged IVH therapy.
Observation:
- A 60-year-old woman developed a widespread vesiculopustular and erythematous eruption during IVH.
- The rash affected the face, perineum, thighs, and feet, accompanied by agitation.
- Negative results for Candida albicans ruled out fungal infection.
Findings:
- Pre-treatment serum zinc levels were markedly depressed at 36 microgram/dl.
- Oral zinc sulfate therapy (220 mg twice daily) led to significant rash resolution within 48 hours.
- The eruption resolved to mild erythema.
Implications:
- This case suggests zinc deficiency as a potential cause of dermatological reactions during IVH.
- Prompt zinc supplementation may effectively treat such IVH-associated skin conditions.
- Monitoring zinc levels in patients receiving long-term IVH is crucial for preventing dermatological complications.