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[Cardiac disorders associated with progressive systemic sclerosis]

N Hata1, T Kunimi, H Matsuda

  • 1Department of Cardiology, National Yokosuka Hospital, Kanagawa.

Journal of Cardiology
|January 23, 1999
PubMed
Summary
This summary is machine-generated.

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Progressive systemic sclerosis frequently causes cardiac disorders, including conduction abnormalities and valvular disease. Pericardial thickening is notably linked to positive anticardiolipin antibodies in these patients.

Area of Science:

  • Cardiology
  • Rheumatology
  • Systemic Autoimmune Diseases

Context:

  • Progressive systemic sclerosis (PSS) is a systemic autoimmune disease affecting multiple organs.
  • Cardiac involvement is a significant complication of PSS, impacting patient prognosis.
  • Previous studies highlight various cardiac manifestations, but specific associations require further investigation.

Purpose:

  • To investigate the prevalence and types of cardiac disorders in patients diagnosed with progressive systemic sclerosis.
  • To assess the relationship between cardiac abnormalities and clinical/serological findings, particularly anticardiolipin antibodies.

Summary:

  • This study examined 25 female patients with PSS, mean age 59 years, mean disease duration 11 years.
  • Abnormal electrocardiograms (ECG) were found in 44% and abnormal echocardiograms in 64%. Common ECG findings included conduction disturbances, while echocardiography revealed valvular diseases and pericardial thickening.

Related Experiment Videos

  • Echocardiographic abnormalities, especially pericardial thickening (63%), were more frequent in patients with positive anticardiolipin antibodies compared to those with negative antibodies (12%, p < 0.05).

    • Impact:

    • Identifies a high prevalence of cardiac disorders in PSS patients.
    • Highlights the significant association between pericardial thickening and positive anticardiolipin antibody status.
    • Suggests routine cardiac evaluation and monitoring for PSS patients, particularly those with specific serological markers.