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Intraperitoneal nutrition

M Wolfson1, M Jones

  • 1Baxter Healthcare Corporation, McGraw Park, IL 60085-6730, USA. wolfsonm@baxter.com

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|January 23, 1999
PubMed
Summary
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Amino acid dialysis solutions provide significant nutritional benefits for peritoneal dialysis (PD) patients. These solutions help improve protein balance and support anabolism, addressing malnutrition effectively.

Area of Science:

  • Nephrology
  • Nutritional Science
  • Biochemistry

Background:

  • Peritoneal dialysis (PD) is a renal replacement therapy.
  • Nutritional support is crucial for PD patients, many of whom suffer from malnutrition.
  • Amino acid provision via dialysis has been explored as a nutritional strategy.

Purpose of the Study:

  • To evaluate the efficacy of a shelf-stable amino acid-based dialysis solution for nutritional supplementation in PD patients.
  • To assess the impact of amino acid absorption on protein and amino acid balance.
  • To determine the tolerability and anabolic effects of amino acid-based solutions.

Main Methods:

  • Utilized a shelf-stable amino acid-based dialysis solution for exchanges in PD patients.
  • Quantitatively assessed amino acid absorption during dialysis exchanges.

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  • Monitored nitrogen balance, insulin-like growth factor-1 (IGF-1) levels, and serum protein concentrations.

    • Main Results:

    • Amino acid absorption during one exchange exceeded daily protein and amino acid losses.
    • The supplementary amino acids were well tolerated by patients.
    • Significant improvements were observed in nitrogen balance, IGF-1 levels, and serum protein concentrations, indicating protein anabolism.
    • These findings suggest a positive impact on the nutritional status of malnourished PD patients.

    Conclusions:

    • Shelf-stable amino acid-based dialysis solutions are a viable and convenient method for nutritional supplementation in PD.
    • These solutions effectively address the nutritional needs of PD patients, promoting protein anabolism and improving overall nutritional status.
    • Amino acid-based PD solutions represent a promising therapeutic option for managing malnutrition in this patient population.