[Lipid composition of high density lipoproteins in familial hyperlipoproteinemias]
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Updated: Oct 26, 2026

A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes
Published on: September 15, 2018
M G Tvorogova1, P N Vasin, T A Rozhkova
1Institute of Clinical Cardiology, Moscow.
Abstract:
The lipid composition of high density lipoproteins was studied in 53 patients with various forms of hereditary hyperlipoproteinemia. 20 healthy individuals formed control group. One-dimensional thin-layer chromatography on silica gel with two solvent systems was used to separate lipid fractions of high density lipoproteins. Ten fractions were identified: four phospholipids (phosphatidylcholine, lysophosphatidylcholine, sphingomyelin, phosphatidylethanolamine) mono-, di-, and triglycerides, free cholesterol, cholesterol esters and free fatty acids. Proportion of HDL phospholipid and cholesterol fraction got by Shimadzu (CS-930) chromato-scanner corresponds to data received with the use of traditional methods. Comparison of high density lipoproteins lipid classes proportions for the individuals with normo- and hyperlipoproteinemia demonstrates increase of lysophosphatidylcholine and decrease of phoshatidylethanolamine for all hereditary hyperlipoproteinemia forms investigated in the study.
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