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Related Experiment Videos

[Should desmoid fibromas be operated?]

V I Chissov, S L Dar'ialova, A V Boĭko

    Khirurgiia
    |January 23, 1999
    PubMed
    Summary

    Soft tissue desmoid fibromas (DF) treatment has evolved significantly. Chemohormonal therapy offers a promising 81.3% recovery rate, surpassing traditional methods with lower recurrence rates.

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    [The choice of reconstructive operation in the treatment of patients with breast cancer].

    Khirurgiia·2013

    Area of Science:

    • Oncology
    • Surgical Oncology
    • Radiation Oncology

    Context:

    • P.A. Herzen Moscou Cancer Research Institute's 30-year experience in treating soft tissue desmoid fibromas (DF).
    • Comparative analysis of surgical, combined, radiation, and medicamentous treatment modalities.
    • Evaluation of recurrence rates across different treatment approaches.

    Purpose:

    • To summarize the institute's extensive experience in managing desmoid fibromas.
    • To compare the efficacy of various treatment strategies for DF.
    • To identify optimal management protocols based on long-term outcomes.

    Summary:

    • Surgical treatment alone resulted in a 94% recurrence rate.
    • Combined treatment with preoperative radiation reduced recurrences to 27.5%, while postoperative radiation showed a 53% recurrence rate.
    • Radiation therapy alone achieved a 15.7% recurrence rate but has limitations due to high-dose irradiation and potential tissue damage.
    • An original chemohormonal therapy (tamoxifen, vinblastine, methotrexate) demonstrated stable recovery in 81.3% of patients.

    Impact:

    • Highlights the limitations of traditional treatments for desmoid fibromas.
    • Introduces chemohormonal therapy as a highly effective alternative with improved patient outcomes.
    • Provides evidence-based recommendations for the clinical management of desmoid fibromas.

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