Related Experiment Video

Updated: Jul 25, 2026

Using Quantitative Real-time PCR to Determine Donor Cell Engraftment in a Competitive Murine Bone Marrow Transplantation Model
10:11

Using Quantitative Real-time PCR to Determine Donor Cell Engraftment in a Competitive Murine Bone Marrow Transplantation Model

Published on: March 7, 2013

An overview of the Czech Bone Marrow Donor Registry

L Kupková1, E Ivasková, I Hána

  • 1Institute Clinical and Experimental Medicine, Charles University, Prague, Czech Republic.

Bone Marrow Transplantation
|January 23, 1999
PubMed

Insights

The Czech Bone Marrow Donor registry (CBMD) facilitates unrelated donor stem cell transplants. Since 1991, CBMD has registered over 7,000 donors and processed nearly 20,000 international requests, aiding numerous life-saving transplantations.

Area of Science:

  • Hematology
  • Immunogenetics
  • Transplantation Medicine

Background:

  • Established in 1991, the Czech Bone Marrow Donor registry (CBMD) operates within the National HLA centre.
  • CBMD is internationally integrated through Bone Marrow Donors Worldwide (BMDW) and the European Donor Secretariat (E.D.S) network.
  • Donor recruitment utilizes blood transfusion units, mass media, and adheres to European Federation for Immunogenetics (EFI) standards.

Purpose of the Study:

  • To detail the establishment and operational scope of the CBMD.
  • To highlight CBMD's role in facilitating unrelated donor stem cell and bone marrow transplantation.
  • To showcase CBMD's international collaboration and request handling capacity.

Main Methods:

  • Registration of potential bone marrow donors typed for HLA-A, B loci.
  • Maintenance of a registry including frozen cord blood units.
  • Processing of international search requests via the E.D.S network.

Main Results:

  • Over 7,000 potential bone marrow donors registered.
  • Nearly 20,000 international requests processed since 1991.
  • In the last two years, 7 CBMD donors contributed to transplants (5 bone marrow, 1 PBSC, 1 bone marrow + PBSC).
  • Over 20 unrelated donor transplantations performed in Prague.

Conclusions:

  • CBMD is a key contributor to unrelated donor hematopoietic stem cell transplantation.
  • The registry's international cooperation and data management are crucial for successful transplants.
  • CBMD plays a vital role in supporting Czech transplant centers and patients.

More Related Videos

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease08:05

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease

Published on: March 17, 2020

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis08:00

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis

Published on: May 26, 2021

Related Concept Videos

Overview of Hematopoiesis01:20

Overview of Hematopoiesis

Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
Blood Transfusion01:15

Blood Transfusion

Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...