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Related Experiment Videos

Formula tolerance in postbreastfed and exclusively formula-fed infants

B Lloyd1, R J Halter, M J Kuchan

  • 1Department of Pediatric Nutrition Research and Development Ross Products Division Abbott Laboratories, Columbus, OH 43215-1724, USA.

Pediatrics
|January 26, 1999
PubMed
Summary

Formula composition impacts infant stool characteristics. Formula A, with a different fat blend, resulted in softer stools compared to Formula B, easing the transition from breast milk.

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Area of Science:

  • Pediatric Nutrition
  • Infant Formula Composition
  • Gastrointestinal Tolerance

Background:

  • Perceived infant formula intolerance is a common reason for switching formulas.
  • Intolerance symptoms include constipation, fussiness, and spit-up.
  • Commercial formulas vary in processing and nutrient composition, potentially affecting tolerance.

Purpose of the Study:

  • To compare the tolerance of two commercially available powder infant formulas with different compositions.
  • To evaluate tolerance in breastfed infants weaned to formula and in exclusively formula-fed infants.

Main Methods:

  • Two clinical studies involving healthy, full-term infants.
  • Study 1: Breastfed infants randomized to formula A or B at weaning.
  • Study 2: Formula-fed infants randomized to formula A or B after initial standard formula.

Related Experiment Videos

  • Tolerance measured by intake volume, weight gain, spit-up/vomit, stool color, and consistency.

    • Main Results:

    • No significant differences in intake volume, weight gain, or spit-up/vomit between groups.
    • Formula B resulted in less frequent and firmer stools compared to Formula A.
    • Stool characteristics differed significantly between infants fed Formula A and Formula B.

    Conclusions:

    • Infant formula composition significantly affects stool characteristics.
    • Formula A's fat blend may promote softer stools, similar to breastfed infants.
    • Formula A may facilitate a smoother transition from breast milk and reduce perceived constipation.