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Perilesional and topical interferon alfa-2b for conjunctival and corneal neoplasia
1Bascom Palmer Eye Institute, University of Miami School of Medicine, Florida 33136, USA.
Objective:
To evaluate the role of combined subconjunctival and topical interferon alfa-2b (IFN alpha 2b) in the treatment of conjunctival and corneal intraepithelial neoplasia (CIN).
Design:
Noncomparative case series.
Participants:
Six patients with histologically proven CIN or recurrences of histologically proven CIN were studied prospectively.
Intervention:
Patients were given a single subconjunctival/perilesional injection of recombinant IFN alpha 2b (Schering Plough, Kenilworth, NJ) 3 million international units (IU) in 0.5 ml and then started receiving topical interferon drops (1 million U/ml) four times a day. Patients were followed weekly until complete resolution of the tumor. After 1 week, patients with minimal response while receiving topical therapy were retreated with perilesional injections three times a week until resolution. Patients received topical interferon drops for a month after clinical resolution of the lesion.
Main Outcome Measures:
Patients were followed clinically and photographically for evidence of tumor resolution.
Results:
The authors present a series of six patients who were treated successfully with a combination of subconjunctival/perilesional and topical IFN alpha 2b. All six patients had complete clinical resolution of the CIN lesion within 6 weeks of initiation of treatment. In the time of follow-up (average, 7.2 months; range, 2-11 months), there have been no treatment failures or recurrences.
Conclusion:
IFN alpha 2b may be a viable medical alternative to surgical excision for primary or recurrent CIN.