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Lung function and morphology after bilateral hilar stripping in dogs
Summary
Hilar stripping in dogs caused airway fluid discharge and decreased cardiac output, but did not alter lung function. Left pneumonectomy showed no significant changes, indicating the lung hilum
Area of Science:
- Pulmonary physiology
- Surgical research
Background:
- The lung hilum is crucial for respiratory and cardiovascular function.
- Understanding the effects of surgical manipulation of the lung hilum is important for thoracic surgery.
Purpose of the Study:
- To investigate the acute effects of hilar stripping and pneumonectomy on lung function and morphology in dogs.
Main Methods:
- Three groups of dogs were studied: bilateral hilar stripping, unilateral hilar stripping with contralateral pneumonectomy, and a control group.
- Lung function tests and histological examinations were performed.
Main Results:
- Hilar stripping induced a syndrome with absent Hering-Breuer reflex, slow respiration, increased tidal volume, airway fluid discharge, and decreased cardiac output and arterial oxygen tension.
- Histology revealed lymphostasis and interstitial edema in stripped lungs.
- Unilateral hilar stripping combined with pneumonectomy did not cause significant changes compared to controls.
Conclusions:
- Functional hilar stripping causes significant acute physiological and morphological changes in the lung.
- Pneumonectomy does not appear to cause significant acute changes when performed unilaterally.