Development and optimisation of a generic micellar electrokinetic capillary chromatography method to support analysis...

A micellar electrokinetic capillary chromatography (MECC) method has been developed and validated to allow the analysis of a wide range of water soluble and insoluble acidic, basic and neutral drugs and excipients. An electronic database has been established to demonstrate the wide applicability of the method. The method has been validated and is now in routine use. In particular, acceptable injection precision is obtained through use of internal standards. Optimal sensitivity was obtained by using low UV wavelength detection. The method allows a number of cost and time saving benefits.