Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Health anxiety: Another epidemic to prepare for].

La Revue de medecine interne·2024
Same author

Efficacy of Mepolizumab for the Treatment of Eosinophilic Cystitis: A Report of 2 Cases.

Journal of investigational allergology & clinical immunology·2023
Same author

[Chronic fatigue: What investigations? And what for?]

La Revue de medecine interne·2023
Same author

[Rhabdomyolysis with tetraparesis secondary to hepatitis E virus infection in a patient on statins].

La Revue de medecine interne·2022
Same author

["Long-haul COVID": An opportunity to address the complexity of post-infectious functional syndromes].

La Revue de medecine interne·2021
Same author

[Spontaneous periodic hypothermia syndrome: A systematic review of the literature].

La Revue de medecine interne·2021

Related Experiment Video

Updated: Jul 27, 2026

Home-Based Transcranial Direct Current Stimulation Device Development: An Updated Protocol Used at Home in Healthy Subjects and Fibromyalgia Patients
11:26

Home-Based Transcranial Direct Current Stimulation Device Development: An Updated Protocol Used at Home in Healthy Subjects and Fibromyalgia Patients

Published on: July 14, 2018

[Fibromyalgia. A critical review]

P Cathébras1, A Lauwers, H Rousset

  • 1Service de Médecine Interne, Hôpital Nord, Saint-Etienne.

Annales De Medecine Interne
|January 28, 1999
PubMed
Summary

Fibromyalgia, a chronic pain condition affecting 2% of the population, presents with widespread pain, fatigue, and sleep issues. Current diagnostic criteria and treatments show limited efficacy, highlighting the need for further research into its complex pathophysiology.

Area of Science:

  • Rheumatology
  • Pain Medicine
  • Psychiatry

Background:

  • Fibromyalgia is a chronic pain syndrome with a 2% prevalence in the general population, disproportionately affecting women.
  • Key symptoms include widespread musculoskeletal pain, fatigue, and sleep disturbances.
  • Existing diagnostic criteria struggle to differentiate fibromyalgia from other functional somatic syndromes and psychiatric disorders due to high comorbidity.

Purpose of the Study:

  • To review the diagnostic challenges and pathophysiological hypotheses of fibromyalgia.
  • To propose a model of interconnected etiological factors contributing to generalized hyperalgesia.
  • To discuss the limited efficacy of current treatments and the prognosis of fibromyalgia.

Main Methods:

  • Literature review of diagnostic criteria, epidemiological data, and pathophysiological theories.

More Related Videos

Efficacy of Fu's Subcutaneous Needling on Sciatic Nerve Pain: Behavioral and Electrophysiological Changes in a Chronic Constriction Injury Rat Model
08:20

Efficacy of Fu's Subcutaneous Needling on Sciatic Nerve Pain: Behavioral and Electrophysiological Changes in a Chronic Constriction Injury Rat Model

Published on: June 30, 2023

A Randomized, Sham-Controlled Trial of Cranial Electrical Stimulation for Fibromyalgia Pain and Physical Function, Using Brain Imaging Biomarkers
08:33

A Randomized, Sham-Controlled Trial of Cranial Electrical Stimulation for Fibromyalgia Pain and Physical Function, Using Brain Imaging Biomarkers

Published on: January 5, 2024

Related Experiment Videos

Last Updated: Jul 27, 2026

Home-Based Transcranial Direct Current Stimulation Device Development: An Updated Protocol Used at Home in Healthy Subjects and Fibromyalgia Patients
11:26

Home-Based Transcranial Direct Current Stimulation Device Development: An Updated Protocol Used at Home in Healthy Subjects and Fibromyalgia Patients

Published on: July 14, 2018

Efficacy of Fu's Subcutaneous Needling on Sciatic Nerve Pain: Behavioral and Electrophysiological Changes in a Chronic Constriction Injury Rat Model
08:20

Efficacy of Fu's Subcutaneous Needling on Sciatic Nerve Pain: Behavioral and Electrophysiological Changes in a Chronic Constriction Injury Rat Model

Published on: June 30, 2023

A Randomized, Sham-Controlled Trial of Cranial Electrical Stimulation for Fibromyalgia Pain and Physical Function, Using Brain Imaging Biomarkers
08:33

A Randomized, Sham-Controlled Trial of Cranial Electrical Stimulation for Fibromyalgia Pain and Physical Function, Using Brain Imaging Biomarkers

Published on: January 5, 2024

  • Analysis of comorbidities with functional somatic and psychiatric disorders.
  • Synthesis of etiological factors into a proposed 'final common pathway' model.

    • Main Results:

    • Current diagnostic criteria lack specificity, complicating differential diagnosis in clinical practice.
    • No single pathophysiological hypothesis fully explains fibromyalgia; muscle, sleep, stress, and psychiatric factors play complex roles.
    • Proposed model suggests vicious circles of etiological contributors leading to generalized hyperalgesia.

    Conclusions:

    • Fibromyalgia diagnosis remains challenging, with current treatments offering limited efficacy.
    • Psychiatric disorders may be vulnerability factors rather than direct causes.
    • The prognosis for fibromyalgia is generally poor, though outcomes may differ outside specialized centers.