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Long-term antibiotic therapy for balanitis xerotica obliterans
W B Shelley1, E D Shelley, M A Grunenwald
1Department of Medicine, Medical College of Ohio, Toledo 43614-5809, USA.
Abstract:
In an open uncontrolled study of 3 patients with balanitis xerotica obliterans we have observed significant improvement after long-term systemic antibiotic therapy. Two of the patients noticed softening of the skin as well as disappearance of pruritus, tenderness, and inflammatory changes within 3 weeks of receiving oral and intramuscular penicillin. The third patient experienced the same degree of improvement after a regimen of dirithromycin, 500 mg/day. Stopping the antiobiotic for 1 month resulted in relapse, with improvement again on resumption.
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