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The prevalence of factor V Leiden mutation in patients with leg ulcers and venous insufficiency

M B Maessen-Visch1, K Hamulyak, D J Tazelaar

  • 1Department of Dermatology, University Hospital Maastricht, The Netherlands.

Archives of Dermatology
|January 29, 1999
PubMed

Insights

The factor V Leiden mutation is more common in patients with venous leg ulcers and chronic venous insufficiency. This mutation increases the risk of deep vein thrombosis and recurrent leg ulcerations.

Area of Science:

  • Vascular Medicine
  • Genetics
  • Dermatology

Background:

  • Chronic venous insufficiency (CVI) and venous leg ulcers (VLUs) are significant clinical challenges.
  • The role of genetic predispositions, such as factor V Leiden mutation, in the pathogenesis of CVI and VLUs requires further elucidation.

Purpose of the Study:

  • To determine the prevalence of factor V Leiden mutation in patients with CVI and VLUs.
  • To compare this prevalence against a control group.
  • To investigate the association between factor V Leiden mutation and a history of deep venous thrombosis (DVT) in patients with CVI.

Main Methods:

  • A case-control study was conducted across three outpatient dermatological clinics.
  • Ninety-two patients diagnosed with venous leg ulcers were compared with 53 control patients.
  • Factor V Leiden mutation was the primary outcome measure assessed.

Main Results:

  • Factor V Leiden mutation was significantly more prevalent in patients with VLUs (23%) compared to controls (7.5%; P=.03).
  • Patients with the mutation had a higher likelihood of a history of venous thromboembolism (91% vs 48%; P=.002).
  • Recurrent DVT (38% vs 14%) and recurrent leg ulcerations (43% vs 19%) were more frequent in the factor V Leiden mutation group.

Conclusions:

  • Factor V Leiden mutation is more frequent in individuals with venous leg ulceration than in the general population.
  • The presence of factor V Leiden mutation is associated with an elevated risk of developing deep venous thrombosis and experiencing recurrent leg ulcerations.
Abstract

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