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Related Experiment Videos

Bacteraemia in cerebral malaria

G Enwere1, M B Van Hensbroek, R Adegbola

  • 1Royal Victoria Hospital, Banjul, The Gambia Laboratory, Fajara, The Gambia.

Annals of Tropical Paediatrics
|January 30, 1999
PubMed
Summary

In Gambian children with cerebral malaria, blood cultures rarely showed bacterial infections (5%). Most identified bacteria were likely contaminants, suggesting routine antibiotics are not needed for cerebral malaria treatment.

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Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Tropical Medicine

Background:

  • Cerebral malaria is a severe complication of Plasmodium falciparum infection.
  • Bacterial co-infections can complicate malaria, but their prevalence in cerebral malaria is not well-established in all regions.
  • Understanding the role of bacterial bloodstream infections in cerebral malaria is crucial for guiding treatment strategies.

Purpose of the Study:

  • To investigate the incidence and types of bacterial bloodstream infections in Gambian children diagnosed with cerebral malaria.
  • To determine if bacterial infections commonly complicate cerebral malaria in this population.
  • To assess the potential need for routine antibiotic therapy in children with cerebral malaria.

Main Methods:

  • Blood cultures were performed on 276 children aged 1-9 years with cerebral malaria in The Gambia.

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  • Organisms isolated from positive blood cultures were identified.
  • Patient outcomes, including survival and antibiotic treatment, were noted.

    • Main Results:

    • Blood cultures were positive in 14 (5%) of the 276 children.
    • The most common isolates included Staphylococcus aureus, coliforms, Pseudomonas spp., Salmonella spp., and Streptococcus spp.
    • Thirteen of the 14 children with positive blood cultures survived, many without specific antibiotic treatment, suggesting potential contamination.

    Conclusions:

    • Bacteraemia complicating cerebral malaria appears uncommon in Gambian children.
    • The majority of positive blood cultures in this study may represent contaminants.
    • Routine antibiotic treatment for children with cerebral malaria in The Gambia is not currently warranted based on these findings.