Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immune privilege in the retina

D S Gregerson1

  • 1Department of Ophthalmology, University of Minnesota, Minneapolis 55455-3007, USA. grege001@tc.umn.edu

Ocular Immunology and Inflammation
|January 30, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Failure of memory (CD44 high) CD4 T cells to recognize their target antigen in retina.

Journal of neuroimmunology·2001
Same author

Local regulation of immune responses: corneal endothelial cells alter t cell activation and cytokine production.

Cytokine·2000
Same author

Systemic expression of rat soluble retinal antigen induces resistance to experimental autoimmune uveoretinitis.

Journal of immunology (Baltimore, Md. : 1950)·1999
Same author

Retinal expression of a neo-self antigen, beta-galactosidase, is not tolerogenic and creates a target for autoimmune uveoretinitis.

Journal of immunology (Baltimore, Md. : 1950)·1999
Same author

Effects of continuous localized infusion of granulocyte-macrophage colony-stimulating factor and inoculations of irradiated glioma cells on tumor regression.

Journal of neurosurgery·1999
Same author

Ex vivo transduction of corneal epithelial progenitor cells using a retroviral vector.

Investigative ophthalmology & visual science·1999
Same journal

Pseudo-Choroidal Melanocytosis in Birdshot Chorioretinitis: A Case Series from a Prospective Cohort.

Ocular immunology and inflammation·2026
Same journal

Clinically Suspected Choroidal Lymphoma Arising from Indolent Nonprogressive Multifocal Choroidal Lesions: A Case Report and Literature Review.

Ocular immunology and inflammation·2026
Same journal

Multimodal Imaging of Choroidal Lymphoma: Diagnostic Features, Differential Diagnosis, and Clinical Monitoring.

Ocular immunology and inflammation·2026
Same journal

Presumed Bilateral Retinitis Associated with JC Virus in a Patient with HIV AIDS.

Ocular immunology and inflammation·2026
Same journal

Safety and Efficacy of Adalimumab in the Treatment of Refractory Behçet's Uveitis: A Prospective Cohort Study.

Ocular immunology and inflammation·2026
Same journal

Role of Adjunctive Intravitreal Therapy in Intraocular Tubercular Granuloma at a Tertiary Uveitis Care Centre - A Retrospective Case Series.

Ocular immunology and inflammation·2026
See all related articles

The retina’s immune privilege, crucial for vision, is primarily maintained by sequestration. When this fails, active immune tolerance mechanisms protect the retina.

Area of Science:

  • Ophthalmology
  • Immunology
  • Neuroscience

Background:

  • Ocular immune privilege is essential for maintaining vision.
  • Established mechanisms include immune deviation and active tolerance.
  • The role of sequestration as a primary protective mechanism requires further investigation.

Purpose of the Study:

  • To re-evaluate the role of sequestration in retinal immune privilege.
  • To propose a hierarchical model of ocular immune privilege.
  • To investigate the interplay between sequestration and active tolerance in the retina.

Main Methods:

  • Review of existing literature on ocular immune privilege.
  • Analysis of experimental data supporting sequestration and active tolerance.
  • Hypothesis formulation based on current immunological understanding.

Related Experiment Videos

Main Results:

  • Sequestration is proposed as the initial and primary line of defense for retinal immune privilege.
  • Active, inducible immune mechanisms serve as a backup when sequestration fails.
  • This hierarchical model integrates old and new paradigms of ocular immune privilege.

Conclusions:

  • Retinal immune privilege relies on a layered defense system.
  • Sequestration acts as the first barrier, followed by active tolerance.
  • Understanding this hierarchy is key to addressing retinal diseases.