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Leukemic pleural effusion in B-cell prolymphocytic leukemia
V Andrieu1, R Encaoua, C Carbon
1Department of Hematology, Hôpital Xavier Bichat-Claude Bernard, Paris, France.
Hematology and Cell Therapy
|January 30, 1999
Summary
Pleural effusion revealing B-cell prolymphocytic leukemia (B-PLL) is rare. Treatment with fludarabine led to complete remission, suggesting potential for new therapies in symptomatic B-PLL.
Area of Science:
- Hematology
- Oncology
Background:
- Leukemic pleural effusion is a rare complication in chronic lymphocytic leukemia.
- It has not been previously reported in B-cell prolymphocytic leukemia (B-PLL).
Observation:
- This report details a case where pleural effusion was the initial presentation of B-cell prolymphocytic leukemia (B-PLL).
- Diagnosis was confirmed through cytological and immunological analysis of blood and pleural fluid cells.
Findings:
- The patient diagnosed with B-PLL presenting with pleural effusion achieved complete remission.
- Remission was observed after three courses of fludarabine treatment.
Implications:
- This case highlights the potential for pleural effusion to be an initial manifestation of B-PLL.
- The successful treatment with fludarabine suggests that adenosine nucleotide analogues may be effective for symptomatic B-PLL.