Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[(A1-beta-Alanine) insulin]

R Geiger, K Geisen, G Regitz

    Hoppe-Seyler'S Zeitschrift Fur Physiologische Chemie
    |September 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Researchers modified porcine insulin by replacing A1-glycine with beta-alanine, creating a new insulin analogue. This analogue exhibits reduced blood sugar-lowering effects and receptor binding compared to native insulin.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Multiphoton Atom Interferometry via Cavity-Enhanced Bragg Diffraction.

    Physical review letters·2024
    Same author

    Degradation of dibutyl phthalate by Paenarthrobacter sp. Shss isolated from Saravan landfill, Hyrcanian Forests, Iran.

    Biodegradation·2021
    Same author

    Prevalence and differences of ideal cardiovascular health in urban and rural adolescents in the Region of Tyrol: results from the EVA Tyrol study.

    BMC cardiovascular disorders·2021
    Same author

    Tailoring Multiloop Atom Interferometers with Adjustable Momentum Transfer.

    Physical review letters·2020
    Same author

    A fibered laser system for the MIGA large scale atom interferometer.

    Scientific reports·2020
    Same author

    Interleaved atom interferometry for high-sensitivity inertial measurements.

    Science advances·2018
    Same journal

    Isolation and amino-acid composition of the adipokinetic hormone of Manduca sexta.

    Hoppe-Seyler's Zeitschrift fur physiologische Chemie·1984
    Same journal

    [The primary structure of human free secretory component and the arrangement of disulfide bonds].

    Hoppe-Seyler's Zeitschrift fur physiologische Chemie·1984
    Same journal

    [Inhibition of acetylcholinesterase using fluorescence-labeled inhibitors].

    Hoppe-Seyler's Zeitschrift fur physiologische Chemie·1984
    Same journal

    Slow migrating proteinase inhibitors in human urine.

    Hoppe-Seyler's Zeitschrift fur physiologische Chemie·1984
    Same journal

    Metabolism of sialic acids from exogenously administered sialyllactose and mucin in mouse and rat.

    Hoppe-Seyler's Zeitschrift fur physiologische Chemie·1984
    Same journal

    Glucose 6-phosphate formation by L-type pentose phosphate pathway reactions of rat liver in vitro: further evidence.

    Hoppe-Seyler's Zeitschrift fur physiologische Chemie·1984
    See all related articles

    Area of Science:

    • Biochemistry
    • Endocrinology
    • Pharmacology

    Context:

    • Insulin is a critical hormone regulating blood glucose.
    • Developing insulin analogues with modified properties is essential for diabetes research.
    • Porcine insulin serves as a starting point for structural modifications.

    Purpose:

    • To synthesize and characterize a novel insulin analogue by substituting A1-glycine with beta-alanine.
    • To evaluate the biological activity and receptor binding affinity of the modified insulin.

    Summary:

    • A new insulin analogue was created by substituting A1-glycine with beta-alanine in porcine insulin.
    • The analogue demonstrated approximately 45% of the blood sugar-lowering effect of native insulin in rabbits.
    • Receptor binding assays showed reduced affinity compared to insulin, with EC50 values of 46% for rat liver receptors and 54% for human lymphocytes.

    Related Experiment Videos

    Impact:

    • This study contributes to understanding structure-activity relationships in insulin analogues.
    • The findings may inform the design of future insulin-based therapeutics.
    • Provides data on the functional consequences of specific amino acid substitutions in insulin.