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Updated: Sep 10, 2026

Imaging In-Stent Restenosis: An Inexpensive, Reliable, and Rapid Preclinical Model
Published on: September 14, 2009
[Is the stress test useful in the detection of post-angioplasty restenosis?]
C Martins1, I João, P Fazendas
1Unidade de Cardiologia de Intervenção, Hospital Garcia de Orta, Almada.
Insights
Late stress testing after coronary angioplasty can identify additional restenosis cases. While chest pain has a higher predictive value, stress tests (PE) detect more restenosis in asymptomatic patients.
Area of Science:
- Cardiology
- Interventional Cardiology
- Diagnostic Testing
Context:
- Restenosis remains a significant limitation following percutaneous coronary angioplasty (PTCA).
- The routine use of exercise stress testing (PE) for detecting restenosis is debated, with guidelines like ACC/AHA not recommending it.
- Late stress testing (3-6 months post-PTCA) offers a potential strategy for identifying silent or symptomatic restenosis.
Purpose:
- To retrospectively evaluate the utility of late (3-6 months) exercise stress testing (PE) in detecting in-stent restenosis after PTCA.
- To compare the positive predictive value of symptomatic angina (CCS class II-IV) versus positive PE for restenosis.
- To assess the role of systematic late PE in identifying additional restenosis cases in a post-PTCA population.
Summary:
- A retrospective study of 121 patients undergoing PTCA found that 59 patients had late follow-up. Among these, 7 reported angina, and 11 had positive stress tests (PE).
- All patients with angina showed restenosis (100% PPV). Positive PE identified restenosis in 9 patients (82% PPV).
- In asymptomatic patients, PE identified 2 cases of restenosis (3.4%) with 2 false positives. Overall, late PE detected 22% of restenosis cases at six months.
Impact:
- Symptomatic angina post-PTCA has a higher positive predictive value for restenosis than exercise stress testing (PE).
- Systematic late PE can identify an additional percentage of patients with restenosis, including asymptomatic individuals.
- These findings suggest a potential role for routine late stress testing in comprehensive post-PTCA surveillance, balancing detection rates with acceptable false positive rates.
Abstract:
Restetenosis is still the greatest limitation of coronary angioplasty (PTCA). The systematic use of ergometry (PE) with the objective of identifying restenosis is controversial and, namely, the ACC/AHA does not recommend its routine use. Our objective was to conduct a retrospective study of the use of PE when performed late (3 to 6 months) for the detection of restenosis. As a protocol, our group performed "late" PE on all the patients without contraindications, the patients with positive ergometry or CCS class II-IV angor submitted to angiographic control. Between January 1996 and July 1997, 121 patients (pts) were submitted to PTCA. Our study population was composed of patients submitted to complete revascularisation with follow-up in our centre: 59 pts (49%) with an average age of 58 +/- 12 years, 82% male. Eighty-three percent of the pts had revascularisation in a context of unstable angina, 10% in the acute phase of myocardial infarction and 7% due to chronic angina. Stents were implanted in 42% of the pts. In the follow-up after six months, 7 pts complained of CCS class II or III angor. The ergometry showed positive electrocardiographic criteria in 11 pts (18.6%). All pts with angor had positive PE. All these pts were submitted to angiographic control; restenosis (residual stenosis equal to or above 50%) was observed in all the patients who complained of angor (100% positive predictive value); restenosis occurred in 9 pts with positive ergometry (82% positive predictive value). In asymptomatic pts, PE indicated 2 pts with restenosis (2/59-3.4%) and two false positive (2/11-18%). At six months, PE detected 22% of the pts with restenosis. In conclusion, complete post-revascularisation angor due to coronary angioplasty has a higher positive predictive value than ergometry. However, the stress test, performed systematically, can identify an additional percentage of pts with restenosis with an acceptable percentage of false positives.
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