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PACAP27 and other neuropeptides in the inferior mesenteric ganglion
1Department of Physiology and Biophysics, Mayo Clinic, Rochester, Minnesota 55905, USA.
Annals of the New York Academy of Sciences
|February 3, 1999
Abstract:
The presence and location of PACAP27-like immunoreactivity (PACAP27-LI) in the colon-inferior mesenteric ganglion (IMG) reflex pathway and the effect of exogenously administered PACAP27 on the excitability of IMG are reported. The results provide morphological and electrophysiological support for the hypothesis that PACAP modulates reflex activity between the large intestine and IMG. The intense excitatory effect would be expected to increase the rate of action potential discharge in IMG neurons, increasing sympathetic drive to the colon thereby decreasing of colonic activity.