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Related Experiment Videos

Vertebrate locomotion--a lamprey perspective

S Grillner1, D Parker, A el Manira

  • 1Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden. sten.grillner@neuro.ki.se

Annals of the New York Academy of Sciences
|February 3, 1999
PubMed
Summary

This review explores how the brain and spinal cord control locomotion using lamprey models. It details cellular mechanisms and neuropeptide modulation influencing neural networks for movement.

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Area of Science:

  • Neuroscience
  • Motor Control
  • Computational Biology

Background:

  • Locomotion control involves complex interactions between the forebrain, brain stem, and spinal cord.
  • The lamprey serves as an ideal model organism for detailed cellular analysis of locomotor networks.
  • Understanding neuronal networks is crucial for deciphering motor control.

Purpose of the Study:

  • To review the contributions of different brain regions to locomotion control.
  • To analyze cellular mechanisms underlying pattern generation in locomotor networks.
  • To investigate the modulatory effects of neuropeptides on neural network function.

Main Methods:

  • Review of existing literature on locomotion control.
  • Cellular analysis of neuronal networks in the lamprey.

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  • Examination of pre- and postsynaptic modulation mechanisms.
  • Investigation of neuropeptide effects on network function.

    • Main Results:

    • Forebrain, brain stem, and spinal cord all play roles in locomotion control.
    • Specific cellular mechanisms are key to generating locomotor patterns.
    • Neuropeptides significantly modulate network function, inducing long-lasting changes (>24h).
    • Both pre- and postsynaptic mechanisms are involved in motor control modulation.

    Conclusions:

    • Lamprey models provide valuable insights into the cellular basis of locomotion.
    • Neuropeptides are potent regulators of neural network activity for movement.
    • Understanding these mechanisms can inform future research in motor control and neurological disorders.