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Intestinal epithelial-mesenchymal cell interactions

M Kedinger1, I Duluc, C Fritsch

  • 1INSERM, Unit 381 Ontogenesis and Pathology of the Gut, Strasbourg, France. Michele.Kedinger@inserm.u-strasbg.fr

Annals of the New York Academy of Sciences
|February 3, 1999
PubMed
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Mesenchymal cells control intestinal development and stem cell maintenance through gene regulation and paracrine signaling. These interactions, influenced by cytokines and hormones, are crucial for intestinal tissue homeostasis.

Area of Science:

  • Gastroenterology
  • Developmental Biology
  • Cell Biology

Background:

  • Intestinal morphogenesis and stem cell maintenance depend on controlled cell interactions.
  • Mesenchymal cells are increasingly recognized for their role in regulating epithelial cell behavior.

Purpose of the Study:

  • To investigate the inductive properties of various mesenchymal cell phenotypes on epithelial cells.
  • To analyze the differential modulation of mesenchymal cell proliferation and metabolism by cytokines.
  • To understand the control of the epithelial-mesenchymal unit by hormonal and exogenous factors.

Main Methods:

  • Utilized novel in vitro and in vivo cellular models.
  • Analyzed diverse mesenchymal cell phenotypes and their effects on epithelial cells.

Related Experiment Videos

  • Investigated the impact of cytokines on mesenchymal cell proliferation and metabolism.

    • Main Results:

    • Mesenchymal cell phenotypes exhibit distinct inductive properties on epithelial cells.
    • Cytokines differentially modulate mesenchymal cell proliferation and metabolic functions.
    • The epithelial-mesenchymal unit is subject to hormonal and exogenous factor control.

    Conclusions:

    • Mesenchymal cells play a critical role in regulating intestinal epithelial cell behavior through gene induction.
    • Cellular cross-talk involving basement membrane molecules and paracrine factors is essential for intestinal homeostasis.
    • The intestinal epithelial-mesenchymal unit is a complex system regulated by multiple intrinsic and extrinsic factors.