Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Central olfactory structures in Pax-6 mutant mice

L López-Mascaraque1, C García, F Valverde

  • 1Instituto Cajal (CSIC), Madrid, Spain. mascaraque@cajal.csic.es

Annals of the New York Academy of Sciences
|February 4, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Influence of one or two successive annual applications of organic fertilisers on the enzyme activity of a soil under barley cultivation.

Bioresource technology·2001
Same author

Ketoconazole-induced conformational changes in the active site of cytochrome P450eryF.

Journal of molecular biology·2001
Same author

Comparative in vitro bacteriostatic and bactericidal activity of trovafloxacin, levofloxacin and moxifloxacin against clinical and environmental isolates of Legionella spp.

International journal of antimicrobial agents·2001
Same author

Serum leptin levels in cattle with different nutritional conditions.

Nutrition research (New York, N.Y.)·2001
Same author

A web page to teach neurology and neuropathology to medical students.

Neuropathology and applied neurobiology·2001
Same author

Constituents of Coriaria ruscifolia fruits.

Fitoterapia·2001

The Pax-6 gene mutation prevents olfactory bulb formation in mice, but central olfactory projections can still develop independently of olfactory receptor neuron input. This highlights the complex development of the olfactory system.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Genetics

Background:

  • Olfactory system development involves axons from olfactory placodes projecting to telencephalic vesicles.
  • Olfactory receptor neuron (ORN) axons are crucial for olfactory bulb (OB) formation and lateral olfactory tract (LOT) development.
  • Previous research suggests central olfactory projections may initiate independently of ORN axon arrival.

Purpose of the Study:

  • To investigate the role of nasal olfactory structures in central olfactory structure formation using a Pax-6 mutant mouse model.
  • To determine if the Pax-6 mutation impacts the development of the olfactory bulb and its connections.
  • To clarify the necessity of ORN axon input for the establishment of central olfactory projections.

Main Methods:

Related Experiment Videos

  • Utilized a Pax-6 mutant mouse model exhibiting absence of nose and eyes.
  • Examined brain structures in Pax-6 mutant mice for olfactory bulb development and axonal projections.
  • Analyzed the formation of the lateral olfactory tract (LOT) in the absence of typical nasal olfactory structures.

    • Main Results:

    • Pax-6 mutant mice, despite lacking a nose and olfactory epithelium, possess an ovoid cellular structure in the rostral brain.
    • Cells within this structure project axons to the piriform cortex, forming a presumptive lateral olfactory tract (LOT).
    • The olfactory bulb (OB) in Pax-6 mutants fails to develop its typical structure due to impaired nasal structure formation.

    Conclusions:

    • The identified structure in Pax-6 mutants represents a rudimentary olfactory bulb (OB) whose development is hindered by the mutation.
    • Olfactory receptor neuron (ORN) axon fibers are essential for OB protrusion and layered formation.
    • Central olfactory projections can be established independently of ORN axon input, suggesting alternative developmental pathways.