[The morphological and functional status of the ovaries in rats administered antitumor preparations]

Experiments were performed on Wistar rats to evaluate comparatively the morphological and functional state of the ovaries in the early and late-term periods after a single injection of a platinum-containing cytostatic drug platidiam and an antibiotic of the anthracycline series farmorubicin. It was found that the antineoplastic agents caused a similar toxic effect on the animal's sexual glands. The number of generative elements in the ovaries decreased in this case and the duration of the estrous cycle, the indices of embryonal death, and the pregnancy index increased.