Diagnosis of malignant epithelial thyroid lesions: fine needle aspiration and histopathologic correlation

Fine needle aspiration is a diagnostic tool useful as a guide to patient management. We believe that its role in solving the diagnostic dilemmas presented by thyroid nodules is still underappreciated. Current fiscal constraints in health care might bring about a wider use of this simple technique to select patients for surgery. Care in sampling a mass is essential to obtain aspirates that are representative of the lesion and adequate in quantity for interpretation. Several aspirates are needed from all but the smallest masses. Most thyroid carcinomas are well-differentiated with a low grade of malignancy. The majority of these are papillary carcinomas, which are easily diagnosed in good cytologic smears. With fine needle aspirates the goal is to diagnose a follicular neoplasm and to separate it from the adenomatoid nodule. The follicular neoplasm then can be classified as adenoma or carcinoma with the histologic sections. The minimally invasive carcinoma still can be challenging to recognize. We hope that the cytologic criteria and histopathologic correlations presented here will help general pathologists who interpret aspirates. We believe that in the near future additional immunohistochemical methods and genetic markers will be used increasingly to discriminate among the neoplasms and to provide prognostic information.