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Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples
Published on: January 21, 2018
Relationship between histamine and physiological changes during the early response to nasal antigen provocation
1Section of Otolaryngology-Head and Neck Surgery, Pritzker School of Medicine, University of Chicago, Chicago, Illinois 60637, USA. fbaroody@surgery.bsd.uchicago.edu
Journal of Applied Physiology (Bethesda, Md. : 1985)
|February 4, 1999
Summary
This study developed a new human model to measure allergic responses. It tracks mediator release and physiological changes, like nasal secretions and airway resistance, after allergen exposure.
Area of Science:
- Allergy and Immunology
- Respiratory Medicine
- Human Physiology
Background:
- Allergic rhinitis involves complex early-phase responses.
- Understanding the temporal dynamics of mediator release and physiological changes is crucial.
Purpose of the Study:
- To establish a human model for simultaneously assessing mediator release and physiological responses during the early allergic reaction.
- To investigate the temporal relationships between mediator release and physiological changes, including the nasonasal reflex.
Main Methods:
- Allergic individuals underwent intranasal antigen challenge using filter paper disks.
- Nasal secretions were collected from both nostrils to evaluate the nasonasal reflex.
- Sneezing, nasal symptoms, nasal airway resistance, and mediator levels (histamine, albumin, lactoferrin) were measured.
Main Results:
- Allergen challenge induced rapid increases in sneezing, nasal secretions, and symptoms.
- Nasal airway resistance increased on the challenged side, while the nasonasal reflex was observed.
- Histamine and albumin levels peaked post-challenge, with lactoferrin paralleling secretion weights.
Conclusions:
- A novel human model effectively captures early allergic responses, including mediator release and physiological changes.
- This model allows for simultaneous measurement of key parameters, aiding in the study of allergic rhinitis mechanisms.
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