Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

An in vitro model for evaluating neural stimulating electrodes

P F Johnson, L L Hench

    Journal of Biomedical Materials Research
    |November 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Single-cell mRNA-regulation analysis reveals cell type-specific mechanisms of type 2 diabetes.

    Nature communications·2025
    Same author

    Making behavioral technology transferable.

    The Behavior analyst·2012
    Same author

    Thermal modeling of laser-densified microlenses.

    Applied optics·2010
    Same author

    Bioactive glass-induced osteoblast differentiation: a noninvasive spectroscopic study.

    Journal of biomedical materials research. Part A·2007
    Same author

    Enhanced differentiation and mineralization of human fetal osteoblasts on PDLLA containing Bioglass composite films in the absence of osteogenic supplements.

    Journal of biomedical materials research. Part A·2006
    Same author

    Discrimination between ricin and sulphur mustard toxicity in vitro using Raman spectroscopy.

    Journal of the Royal Society, Interface·2006
    Same journal

    Optimizing the tensile properties of polyvinyl alcohol hydrogel for the construction of a bioprosthetic heart valve stent.

    Journal of biomedical materials research·2002
    Same journal

    Wear of conventional and cross-linked ultra-high-molecular-weight polyethylene acetabular cups against polished and roughened CoCr femoral heads in a biaxial hip simulator.

    Journal of biomedical materials research·2002
    Same journal

    Immobilization of natural macromolecules on poly-L-lactic acid membrane surface in order to improve its cytocompatibility.

    Journal of biomedical materials research·2002
    Same journal

    Light scattering and in vitro biocompatibility studies of poly (vinyl pyrrolidone) derivatives with amino-acid-dependent groups.

    Journal of biomedical materials research·2002
    Same journal

    Immobilization of an oxalate-degrading enzyme on silicone elastomer.

    Journal of biomedical materials research·2002
    Same journal

    An evaluation of the cytotoxic effects of orthodontic bonding adhesives upon a primary human oral gingival fibroblast culture and a permanent, human oral cancer-cell line.

    Journal of biomedical materials research·2002
    See all related articles

    A new in vitro model evaluates neural stimulation electrode materials. This model quantifies material corrosion response, aiding in the selection of reliable materials for neural implants.

    Area of Science:

    • Biomaterials Science
    • Neurotechnology
    • Materials Engineering

    Background:

    • Neural stimulation electrodes are crucial for neuroprosthetic devices.
    • Evaluating material performance in vitro is essential for device safety and efficacy.
    • Existing evaluation methods lack comprehensive quantitative analysis for corrosion response.

    Purpose of the Study:

    • To develop and present a robust in vitro model for evaluating neural stimulation electrode materials.
    • To establish a quantitative method for assessing material response to stimulation conditions.
    • To introduce a diagnostics matrix for comparative analysis of material corrosion.

    Main Methods:

    • Development of an in vitro test environment simulating physiological conditions.

    Related Experiment Videos

  • Utilizing scanning electron microscopy (SEM), X-ray spectroscopy, and atomic absorption spectrometry for material analysis.
  • Employing potentiographic and dielectric analysis to assess electrode performance.
  • Implementing a novel diagnostics matrix to quantify relative corrosion response.

    • Main Results:

    • A quantitative method for analyzing material response to neural stimulation was established.
    • The diagnostics matrix provides a scale factor to rank material corrosion resistance.
    • Platinum (Pt) electrodes were evaluated, demonstrating the matrix's utility in quantifying corrosion response.

    Conclusions:

    • The developed in vitro model provides a standardized approach for evaluating neural stimulation electrode materials.
    • Quantitative analysis and the diagnostics matrix enable objective comparison of material candidates.
    • This model facilitates the selection of durable and biocompatible materials for neural interfaces.