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Spontaneous conception after the birth of infants conceived through in vitro fertilization treatment
Y Shimizu1, H Kodama, J Fukuda
1Department of Obstetrics and Gynecology, Akita University School of Medicine, Japan. shimizuy@obgyn.med.akita-u.ac.jp
Objective:
To investigate the incidence of spontaneous conception after the birth of infants conceived through IVF in couples with subfertility caused by endometriosis, a mild male factor, or unexplained factors, and to identify clinical conditions related to the occurrence of spontaneous conception.
Design:
Retrospective analysis.
Setting:
Department of Obstetrics and Gynecology, Akita University School of Medicine, Akita, Japan.
Patient(S):
One hundred forty-two women who conceived through IVF and 25 of the 142 women who subsequently conceived spontaneously.
Intervention(S):
Patient characteristics and IVF data were obtained from hospital records, and follow-up data were collected through telephone interviews.
Main Outcome Measure(S):
Cumulative conception rate.
Result(S):
The cumulative conception rate at 60 months after the delivery of infants conceived through IVF was 18%, with most conceptions occurring within 2 years of delivery. Proportional hazard analysis indicated that patient age was the most important clinical variable related to the occurrence of spontaneous conception.
Conclusion(S):
This study provides information that will be useful in counseling subfertile couples who have conceived through the use of IVF.