Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Glomerular morphology in nephrotic heroin addicts

E Grishman, J Churg, J G Porush

    Laboratory Investigation; a Journal of Technical Methods and Pathology
    |November 1, 1976
    PubMed
    Summary

    Heroin-associated nephrotic syndrome is most commonly focal segmental glomerular sclerosis. These kidney conditions in heroin users may represent stages of a single disease, possibly toxic in origin.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Systemic necrotizing vasculitis.

    Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2015
    Same author

    The Mesangium of the Renal Glomerulus: Electron Microscopic Studies of Pathologic Alterations.

    The American journal of pathology·2009
    Same author

    Regional expression of inducible nitric oxide synthase in the kidney stimulated by lipopolysaccharide in the rat.

    Experimental physiology·2002
    Same author

    Regional expression of inducible nitric oxide synthase in the kidney in dogs with unilateral ureteral obstruction.

    The Journal of urology·2001
    Same author

    Idiopathic polymyositis and glomerulonephritis.

    Journal of nephrology·2001
    Same author

    Membranous nephropathy and prostatic carcinoma.

    Nephron·2000

    Area of Science:

    • Nephrology
    • Toxicology
    • Pathology

    Background:

    • Nephrotic syndrome is a complex kidney disorder.
    • Heroin abuse is linked to various renal pathologies.
    • Understanding the specific kidney damage in heroin users is crucial.

    Purpose of the Study:

    • To investigate the renal pathology in heroin addicts presenting with nephrotic syndrome.
    • To characterize the light and electron microscopic findings.
    • To explore potential causes and disease progression.

    Main Methods:

    • Analysis of renal biopsies from 23 heroin addicts using light and electron microscopy.
    • Clinical follow-up of 15 patients for 2 months to 5 years.

    Main Results:

    • Focal segmental glomerular sclerosis was the most common finding (14/23 patients).
    • Minimal change disease and focal global sclerosis were also observed.
    • Podocyte changes, including foot process effacement, were prominent on electron microscopy.
    • Membranous nephropathy was notably absent.
    • Eight of 15 followed patients progressed to renal failure.

    Conclusions:

    • Nephrotic syndrome in heroin addicts is frequently associated with focal segmental glomerular sclerosis, minimal change disease, or focal global sclerosis.
    • These findings suggest a potential toxic etiology, possibly related to heroin or its contaminants.
    • The observed renal lesions share similarities with experimental drug-induced nephrosis.

    Related Experiment Videos