[The effect of atropine on the ultrastructural postsynaptic plasticity of the associative type in the rat neocortex]
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1Department of Higher Nervous Activity, Lomonosov State University, Moscow.
Abstract:
The effect of muscarinic antagonist atropine on thickness of postsynaptic density of axodendritic synapses was studied in the sensorimotor region of the brain cortex of rats during paired repeated microapplication of glutamate and acetylcholine. In the applied conditioning paradigm atropine significantly decreased morphological dimensions of the postsynaptic density, however, the control values were not reached. This finding testifies to participation of both muscarinic and nicotinic cholinoreceptors in associative postsynaptic plasticity.
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