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Oral lichen planus and HLA A
M Ognjenović1, D Karelović, V V Cindro
1Clinical Hospital Split, Department of Obstetric and Gynecology, Croatia.
Collegium Antropologicum
|February 10, 1999
Summary
Human leukocyte antigen (HLA) A variations are linked to oral lichen planus (OLP). Specific HLA A types, like w19 and A28, are less common in OLP patients, while A11 and A26 are associated with erosive OLP.
Area of Science:
- Immunogenetics
- Oral Medicine
- Dermatology
Background:
- Oral lichen planus (OLP) is an autoimmune condition affecting oral mucosa, potentially with skin involvement.
- The development of squamous cell carcinoma in OLP erosions necessitates patient monitoring.
- Genetic factors and cell-mediated immunity are implicated in OLP pathogenesis.
Purpose of the Study:
- To investigate the association between Human Leukocyte Antigen (HLA) A alleles and the risk of developing OLP.
- To determine if specific HLA A alleles are linked to the erosive subtype of OLP.
Main Methods:
- A case-control study comparing HLA A allele frequencies in 50 OLP patients with 1089 healthy controls.
- Statistical analysis to identify significant differences in allele frequencies between patient groups and controls.
Main Results:
- OLP patients exhibited significantly lower frequencies of HLA A w19 (3-fold less) and HLA A28 (5-fold less) compared to controls.
- The erosive OLP subtype showed a 4-fold lower frequency of HLA A11 and a 2-fold lower frequency of HLA A26 compared to the plaque form.
Conclusions:
- HLA A w19 and A28 alleles are associated with a reduced risk of OLP.
- HLA A11 and A26 alleles are specifically associated with the erosive form of oral lichen planus.